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    • Arthroplasty in patients with rare conditions
      Open Access

      Gunshot Wound to the Hip Resulting in a Femoral Head and Acetabulum Fracture Treated With Open Reduction and Internal Fixation and Bipolar Hemiarthroplasty

      Arthroplasty Today
      Vol. 16p229–236Published online: July 19, 2022
      • Murphy P. Martin III
      • Matthew W. Cole
      • Akshar H. Patel
      • William F. Sherman
      Cited in Scopus: 0
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        Combined fractures of the femoral head and acetabulum due to ballistic injuries are rare injuries, especially in the elderly. We present a case of a 70-year-old female who sustained a gunshot wound to the left hip, resulting in a comminuted femoral head fracture and posterior wall acetabular fracture. She was treated with open reduction and internal fixation of the acetabulum, as well as bipolar hemiarthroplasty for treatment of her femoral head fracture. At her 18-month follow-up visit, the patient was doing well and had no complaints.
        Gunshot Wound to the Hip Resulting in a Femoral Head and Acetabulum Fracture Treated With Open Reduction and Internal Fixation and Bipolar Hemiarthroplasty
      • Arthroplasty in patients with rare conditions
        Open Access

        Total Knee Arthroplasty With Patient-Specific Instrumentation to Correct Severe Valgus Deformity in a Patient With Hereditary Multiple Exostoses

        Arthroplasty Today
        Vol. 16p175–181Published online: June 24, 2022
        • Urara Sasaki
        • Masashi Tamaki
        • Tetsuya Tomita
        • Seiji Okada
        Cited in Scopus: 0
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          Patients with hereditary multiple exostosis develop several benign osseocartilaginous bulge lesions throughout the body. A 62-year-old woman presented for evaluation of worsening left knee valgus deformity, and left knee pain. She had been diagnosed with hereditary multiple exostosis at the age of 12 years. Radiographic evaluation of the left knee revealed exostoses that caused continuous bulges from cortical bone at the metaphyseal regions of the femur and tibia as well as extra-articular deformity.
          Total Knee Arthroplasty With Patient-Specific Instrumentation to Correct Severe Valgus Deformity in a Patient With Hereditary Multiple Exostoses
        • Arthroplasty in patients with rare conditions
          Open Access

          Outcomes of Total Knee Arthroplasty in Patients With a Prior Contralateral Above-Knee Amputation: A Retrospective Review of a Nationwide Database

          Arthroplasty Today
          Vol. 14p36–39Published online: February 3, 2022
          • Ahmed H. Elhessy
          • Sahir S. Pervaiz
          • Mehdi Abouei
          • Janet D. Conway
          Cited in Scopus: 0
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            Total knee arthroplasty (TKA) in patients with a prior contralateral above-knee amputation (AKA) is uncommon, with limited literature describing the outcomes. We used a national database to compare the outcomes of primary TKA in above-knee amputees and nonamputees.
            Outcomes of Total Knee Arthroplasty in Patients With a Prior Contralateral Above-Knee Amputation: A Retrospective Review of a Nationwide Database
          • Arthroplasty in patients with rare conditions
            Open Access

            Parsonage-Turner Syndrome and Closed-Incision Negative-Pressure Wound Therapy After Total Hip Arthroplasty in a Case of Marfan Syndrome

            Arthroplasty Today
            Vol. 14p1–5Published online: January 19, 2022
            • Seyed Mohammad Javad Mortazavi
            • Mohammadreza Razzaghof
            • Mohammad Ali Ghasemi
            Cited in Scopus: 0
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              Negative pressure wound therapy (NPWT) is a postoperative wound care method, which has recently become an ongoing field of research in hip and knee arthroplasty. We report the successful management of wound dehiscence and infection after THA in a case of Marfan syndrome by closed-incision negative-pressure wound therapy (ciNPWT). Our patient also developed a rare postoperative neurologic complication, that is, Parsonage-Turner syndrome (PTS). To our knowledge, this is the first report of PTS and ciNPWT use for SSI after THA in a Marfan patient.
              Parsonage-Turner Syndrome and Closed-Incision Negative-Pressure Wound Therapy After Total Hip Arthroplasty in a Case of Marfan Syndrome
            • Arthroplasty in patients with rare conditions
              Open Access

              Staged Bilateral Total Knee Arthroplasty for Neglected Blount Disease Using a Gap Balancing Technique

              Arthroplasty Today
              Vol. 11p25–31Published online: August 13, 2021
              • Adam J. Taylor
              • William Carpenter
              • Robert P. Runner
              Cited in Scopus: 0
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                Blount disease is an acquired, asymmetrical disorder of proximal tibial growth that results in a complex three-dimensional proximal tibial deformity, with tibial varus being the dominating feature. Although the exact pathophysiology is unknown, Blount disease is separated into 2 clinical variants, infantile and adolescent, based on the onset of symptoms occurring before or after the age of 10 years. If recognized and treated early, affected patients generally have a favorable prognosis; however, if neglected, it can lead to progressive malalignment and premature osteoarthritis.
                Staged Bilateral Total Knee Arthroplasty for Neglected Blount Disease Using a Gap Balancing Technique
              • Arthroplasty in patients with rare conditions
                Open Access

                Segmental Fractures of the Neck of Femur: Fix or Replace?

                Arthroplasty Today
                Vol. 8p247–252Published online: April 16, 2021
                • Stef Biesemans
                • Wim Vandesande
                Cited in Scopus: 0
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                  Combined intracapsular and extracapsular fractures of the proximal femur—segmental fractures of neck of femur (SFNOF)—are rare and complex injuries. Literature regarding SFNOF is very limited; only one small retrospective study and 19 unique case reports have been described. We report the case of a 42-year-old man who suffered a compound subcapital femur fracture type Garden IV and an ipsilateral multifragmentary greater trochanter fracture from severe crush trauma. Neither the precise fracture constellation nor our management strategy, primary cemented total hip arthroplasty combined with tension band cerclage and triple K-wire trochanteric fixation, has been described in contemporary literature.
                  Segmental Fractures of the Neck of Femur: Fix or Replace?
                • Arthroplasty in patients with rare conditions
                  Open Access

                  Complex Primary Total Knee Arthroplasty in a Patient with Achondroplasia, Osteoarthritis, and Severe Coronal Instability

                  Arthroplasty Today
                  Vol. 8p24–28Published online: February 24, 2021
                  • Ryan Stancil
                  • Michael Goldberg
                  • Maryse Bouchard
                  • Adam Sassoon
                  Cited in Scopus: 0
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                    Genu varum in patients with achondroplasia is common and is often exacerbated by the associated generalized ligamentous laxity. Despite this, development of knee osteoarthritis is rare. There are only a few previously published case reports of total knee arthroplasty in this population. We present 2-year follow-up of a patient with achondroplasia who underwent staged bilateral primary total knee arthroplasties using hinged components. Technical considerations and careful preoperative planning are required in patients with achondroplasia given their small skeletal stature, metaphyseal deformities, and ligamentous laxity.
                    Complex Primary Total Knee Arthroplasty in a Patient with Achondroplasia, Osteoarthritis, and Severe Coronal Instability
                  • Arthroplasty in patients with rare conditions
                    Open Access

                    Bilateral Total Hip Arthroplasty in the Setting of Developmental Dysplasia of the Hip and Extreme Hip Flexion Requirements due to Phocomelia

                    Arthroplasty Today
                    Vol. 8p262–267.e1Published online: February 22, 2021
                    • Akshar H. Patel
                    • Stefan W. Kreuzer
                    • William F. Sherman
                    Cited in Scopus: 0
                    Online Extra
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                      Phocomelia is a rare congenital birth defect marked by hypoplastic or markedly absent limbs. Developmental dysplasia of the hip (DDH) is a congenital disorder with a failure of the native acetabulum to provide complete coverage over the femoral head. The secondary osteoarthritis that develops from DDH is technically challenging for orthopedic surgeons because of distorted anatomy. The present case describes the diagnosis of Crowe 3 DDH in a phocomelia patient with hyperflexion requirements who successfully underwent staged bilateral total hip arthroplasty via a direct anterior approach.
                      Bilateral Total Hip Arthroplasty in the Setting of Developmental Dysplasia of the Hip and Extreme Hip Flexion Requirements due to Phocomelia
                    • Arthroplasty in patients with rare conditions
                      Open Access

                      Spinopelvic Instability in Conversion Total Hip Arthroplasty: A Complicated Case of Loeys-Dietz Syndrome

                      Arthroplasty Today
                      Vol. 6Issue 4p1009–1015Published online: November 20, 2020
                      • Jorge De Leon
                      • Farhan Ahmad
                      • Kavina Patel
                      • Frank Buttacavoli
                      Cited in Scopus: 0
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                        A 53-year-old patient with a history of Loeys-Dietz syndrome (LDS) presented with cutout after a right femoral neck fracture treated with a dynamic hip screw. This was treated with conversion total hip arthroplasty (THA), the second reported THA in a patient with LDS and the first in a post-traumatic reconstruction setting. The patient had 2 episodes of posterior hip dislocations within 2 weeks after the operation requiring a revision THA utilizing dual-mobility bearing to achieve stability. LDS is a connective-tissue disorder that is associated with joint hypermobility and spinal deformities, among other features.
                        Spinopelvic Instability in Conversion Total Hip Arthroplasty: A Complicated Case of Loeys-Dietz Syndrome
                      • Arthroplasty in patients with rare conditions
                        Open Access

                        Bilateral Posterior-Stabilized Total Knee Arthroplasty in a Patient With Osteopetrosis and Literature Review

                        Arthroplasty Today
                        Vol. 6Issue 4p866–871Published online: October 30, 2020
                        • David Beaton Comulada
                        • Lenny Rivera
                        • Gabriel Echegaray
                        • Roberto Colón
                        • Samuel Rodríguez-Santiago
                        • Antonio Otero
                        Cited in Scopus: 2
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                          We present a case report of a patient with osteopetrosis and refractory bilateral knees osteoarthritis who underwent bilateral total knee arthroplasties (TKAs). After conservative management has failed, surgical treatment with arthroplasty is an excellent alternative with satisfactory outcomes. TKA in patients with osteopetrosis has only been described in 6 other case studies, none of which underwent bilateral TKA. To perform this procedure, additional attention should be directed toward the presurgical planning because of the amplified difficulty of the procedure and the altered bone biology that increases the risks of intraoperative fractures and markedly extends the time of surgery.
                          Bilateral Posterior-Stabilized Total Knee Arthroplasty in a Patient With Osteopetrosis and Literature Review
                        • Arthroplasty in patients with rare conditions
                          Open Access

                          Accelerometer-Based, Computer-Navigated Total Knee Arthroplasty to Correct a Complex Deformity in a Patient With Multiple Hereditary Exostoses

                          Arthroplasty Today
                          Vol. 6Issue 4p796–802Published online: September 8, 2020
                          • Bhavik H. Patel
                          • Erik Zeegen
                          • Adam Sassoon
                          Cited in Scopus: 3
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                            Accelerometer-based computer-assisted navigation systems (ABCANSs) have been shown to improve alignment accuracy in total knee arthroplasty (TKA) and are effective in treating complex extra-articular deformity. We present an ABCANS-assisted TKA performed in a 68-year-old male with end-stage arthritis of the right knee, in the setting of a severe valgus deformity secondary to multiple hereditary exostoses.
                            Accelerometer-Based, Computer-Navigated Total Knee Arthroplasty to Correct a Complex Deformity in a Patient With Multiple Hereditary Exostoses
                          • Arthroplasty in patients with rare conditions
                            Open Access

                            Outcomes of Total Knee Arthroplasty with a Prior Contralateral Above-Knee Amputation: A Report of 10 Cases

                            Arthroplasty Today
                            Vol. 6Issue 4p766–769Published online: August 31, 2020
                            • Timothy G. Visser
                            • Mark W. Mason
                            Cited in Scopus: 1
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                              Total knee arthroplasty (TKA) in the setting of a prior contralateral above-knee amputation (AKA) represents a rare scenario with limited reported outcomes. As such, it is difficult for surgeons to effectively counsel these patients relative to risks and expected outcomes after TKA. We report outcomes for a series of 10 such patients.
                            • Arthroplasty in patients with rare conditions
                              Open Access

                              Long-Term Outcomes of the Knee and Hip Arthroplasties in Patients with Alkaptonuria

                              Arthroplasty Today
                              Vol. 6Issue 4p689–693Published online: August 23, 2020
                              • Jihad M. Al-Ajlouni
                              • Mohammed S. Alisi
                              • Mohamad S. Yasin
                              • Aws Khanfar
                              • Mohammad Hamdan
                              • Ahmad Abu Halaweh
                              • and others
                              Cited in Scopus: 1
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                                Alkaptonuria is a rare autosomal recessive metabolic disorder. It is characterized by the accumulation of homogentisic acid in the body due to a lack of enzymes that degrade it. Over time, it results in joint degeneration and eventually leads to ochronosis. Ochronosis refers to bluish-black discoloration of connective and other tissues within the body. In this study, we present 5 distinct cases diagnosed with alkaptonuria. They have undergone 8 total joint replacement surgeries (4 hips and 4 knees) within 8 years (2010-2018).
                                Long-Term Outcomes of the Knee and Hip Arthroplasties in Patients with Alkaptonuria
                              • Arthroplasty in patients with rare conditions
                                Open Access

                                Rapidly Progressive Osteoarthritis and Acetabular Bone Loss Outcomes for Patients Undergoing Primary Total Hip Replacement

                                Arthroplasty Today
                                Vol. 6Issue 3p289–295Published online: June 1, 2020
                                • Paul Karayiannis
                                • Andrew Walls
                                • Roslyn Cassidy
                                • David Beverland
                                Cited in Scopus: 3
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                                  Rapidly progressive osteoarthritis (RPO) is a rare condition which is poorly understood. Limited published literature is available. Reported here is a cohort of patients with RPO and acetabular bone loss who underwent primary THA. Risk factors, degree of acetabular bone loss and outcomes are presented. A typical case of RPO is described and investigations discussed. A retrospective audit was undertaken. 49 patients over an 18-year period were included. RPO patients were significantly older (P < 0.01) and had a lower BMI (P = 0.03).
                                  Rapidly Progressive Osteoarthritis and Acetabular Bone Loss Outcomes for Patients Undergoing Primary Total Hip Replacement
                                • Arthroplasty in patients with rare conditions
                                  Open Access

                                  Total Hip Arthroplasty for the Sequelae of Femoral Neck Fractures in the Pediatric Patient

                                  Arthroplasty Today
                                  Vol. 6Issue 3p296–304Published online: June 1, 2020
                                  • Safa C. Fassihi
                                  • Ryan Mortman
                                  • Jacob Shalkevich
                                  • Danny Lee
                                  • William T. Stoll
                                  • Savyasachi Thakkar
                                  Cited in Scopus: 0
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                                    Although rare, total hip arthroplasty (THA) may be indicated in pediatric patients with degenerative changes of the hip joint after previous trauma. To illustrate management principles in this patient population, this study describes the case of a 15-year-old female who sustained bilateral femoral neck fractures after a generalized tonic-clonic seizure, an atypical, low-energy mechanism for this injury. These fractures were not diagnosed until 14 weeks after the seizure episode, at which point they had progressed to nonunion on the left side, malunion on the right side, and degenerative hip joint changes were developing bilaterally.
                                    Total Hip Arthroplasty for the Sequelae of Femoral Neck Fractures in the Pediatric Patient
                                  • Arthroplasty in patients with rare conditions
                                    Open Access

                                    Drug-Induced Thrombocytopenia Secondary to Commonly Used Antibiotics in Total Joint Arthroplasty

                                    Arthroplasty Today
                                    Vol. 6Issue 2p137–140Published online: April 23, 2020
                                    • Ian Savage-Elliott
                                    • Victor J. Wu
                                    • Fernando L. Sanchez
                                    Cited in Scopus: 2
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                                      Drug-induced thrombocytopenia secondary to antibiotic exposure is a rare complication more commonly associated with other medications. In this review, we present a case of antibiotic-induced thrombocytopenia and discuss the clinical picture and approach to identifying the complication. With increasing use of antibiotics that may be associated with drug-induced thrombocytopenia in perioperative prophylaxis protocols, surgeons need to be cognizant of this cause of thrombocytopenia in the postoperative patient.
                                      Drug-Induced Thrombocytopenia Secondary to Commonly Used Antibiotics in Total Joint Arthroplasty
                                    • Arthroplasty in patients with rare conditions
                                      Open Access

                                      Total knee arthroplasty in hemophilia A

                                      Arthroplasty Today
                                      Vol. 6Issue 1p52–58.e1Published online: March 6, 2020
                                      • Neil Pathak
                                      • Alana M. Munger
                                      • Ahmad Charifa
                                      • William B. Laskin
                                      • Emily Bisson
                                      • Gary M. Kupfer
                                      • and others
                                      Cited in Scopus: 4
                                      Online Extra
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                                        Hemophilia A is a rare genetic disorder involving a deficiency of clotting factor VIII. Coagulation factor replacement therapy has prolonged the life expectancy of patients with hemophilia, but recurrent hemarthrosis of major joints is often a common occurrence. Therefore, orthopaedic adult reconstructive surgeons increasingly encounter hemophilic arthropathy in young adults and consider treating with total joint arthroplasty. In this report, the authors describe a patient with hemophilia A and severe knee osteoarthritis, who was subsequently treated with primary total knee arthroplasty.
                                        Total knee arthroplasty in hemophilia A
                                      • Arthroplasty in patients with rare conditions
                                        Open Access

                                        Total knee arthroplasty in osteogenesis imperfecta

                                        Arthroplasty Today
                                        Vol. 5Issue 2p176–180Published online: October 22, 2018
                                        • Jordan Brand
                                        • Vineet Tyagi
                                        • Lee Rubin
                                        Cited in Scopus: 3
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                                          Osteogenesis imperfecta is a genetic disease resulting in abnormal collagen formation, with multiple clinical manifestations. Advancements in medical and surgical treatments have prolonged the life expectancy of these patients in recent decades. As a result, orthopedic surgeons are likely to be faced with the challenge of performing arthroplasty in these patients on a more frequent basis. Here, we describe a patient with osteogenesis imperfecta and subsequent severe osteoarthritis prompting primary total knee arthroplasty.
                                          Total knee arthroplasty in osteogenesis imperfecta
                                        • Arthroplasty in patients with rare conditions
                                          Open Access

                                          Femoral artery injury during total hip arthroplasty

                                          Arthroplasty Today
                                          Vol. 4Issue 4p459–463Published online: August 16, 2018
                                          • Shuai An
                                          • Huiliang Shen
                                          • Mingli Feng
                                          • Zheng Li
                                          • Yining Wang
                                          • Guanglei Cao
                                          Cited in Scopus: 11
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                                            There are an increasing number of vascular complications after hip replacement, some of which can be life-threatening. However, there are few reports of lower limb ischemic symptoms after undergoing an otherwise uncomplicated classic total hip replacement. We report a patient with low weight who developed postoperative limb ischemia resulting from blood clots caused by insertion of a Hohmann retractor close to small anterior acetabular osteophytes. Ultrasonography and angiography revealed her symptoms to be the result of femoral artery intimal injury with lower extremity arterial thrombosis, which led to pain, numbness, and decreased skin temperature.
                                            Femoral artery injury during total hip arthroplasty
                                          • Arthroplasty in patients with rare conditions
                                            Open Access

                                            Hip arthroplasty for osteonecrosis of the femoral head secondary to alcohol abuse

                                            Arthroplasty Today
                                            Vol. 5Issue 2p172–175Published online: August 11, 2018
                                            • Danielle Y. Ponzio
                                            • Michael Pitta
                                            • Kaitlin M. Carroll
                                            • Michael Alexiades
                                            Cited in Scopus: 4
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                                              Although the challenges of hip arthroplasty for avascular necrosis (AVN) are known, limited data exist to describe patient demographics and outcomes in the setting of AVN attributed to alcoholism. We retrospectively identified 43 patients (62 hips) who underwent primary hip arthroplasty between 1999 and 2016 for a diagnosis of AVN of the femoral head with a concomitant diagnosis of alcohol abuse and minimum follow-up of 2 years (mean, 8.6 years). The mean age was 51 years, predominantly male (88%), with a high rate of comorbidities.
                                            • Arthroplasty in patients with rare conditions
                                              Open Access

                                              Total knee replacement in patients with osteoarthritis and concomitant inveterate patellar dislocation

                                              Arthroplasty Today
                                              Vol. 5Issue 1p68–72Published online: May 28, 2018
                                              • David Figueroa
                                              • Alan Garín
                                              • Francisco Figueroa
                                              Cited in Scopus: 4
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                                                The inveterate patellar dislocation is an uncommon entity. The most frequent findings correspond to a misaligned valgus associated with lateral patellar dislocation. When severe knee osteoarthritis is present, total knee arthroplasty is an option, whether it is associated or not with realignment of the extensor apparatus. We present a review of published literature on correction of inveterate patellar dislocation associated with knee arthritis and our surgical technique with a case of inveterate patellar dislocation associated with tricompartmental knee osteoarthritis, in which a total knee arthroplasty was performed associated with proximal and distal realignment of the extensor apparatus.
                                                Total knee replacement in patients with osteoarthritis and concomitant inveterate patellar dislocation
                                              • Arthroplasty in patients with rare conditions
                                                Open Access

                                                Total knee arthroplasty in patients with multiple hereditary exostoses

                                                Arthroplasty Today
                                                Vol. 4Issue 3p325–329Published online: February 2, 2018
                                                • Samuel A. Fernandez-Perez
                                                • Julio A. Rodriguez Jr.
                                                • David Beaton-Comulada
                                                • Roberto G. Colon-Miranda
                                                • Antonio H. Soler-Salas
                                                • Antonio Otero-Lopez
                                                Cited in Scopus: 3
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                                                  We present a case report of a patient with severe valgus deformity of the right knee due to multiple hereditary exostoses (MHEs) treated with total knee arthroplasty (TKA). The surgical management of MHE affecting the knee encompasses exostoses resection, joint deformity rectification, and limb-length discrepancy alignment. On rare occasions, distraction osteogenesis and TKA have been used to correct valgus deformities of the knee. TKA in MHE patients with knee involvement has only been described in 6 cases.
                                                  Total knee arthroplasty in patients with multiple hereditary exostoses
                                                • Arthroplasty in patients with rare conditions
                                                  Open Access

                                                  Joint replacement surgery in homeless veterans

                                                  Arthroplasty Today
                                                  Vol. 3Issue 4p253–256Published online: May 6, 2017
                                                  • Chase G. Bennett
                                                  • Laura Y. Lu
                                                  • Kathleen A. Thomas
                                                  • Nicholas J. Giori
                                                  Cited in Scopus: 6
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                                                    Total joint arthroplasty (TJA) in a homeless patient is generally considered contraindicated. Here, we report our known medical and social (housing and employment) results of homeless veterans who had TJA. Thirty-seven TJAs were performed on 33 homeless patients (31 men) at our hospital between November 2000 and March 2014. This was 1.2% of all TJAs. Average age was 54 years. Average hospital stay was 4.1 days. There were no major inpatient complications. Thirty-four cases had at least 1-year follow-up in any clinic within the Veterans Affairs health care system.
                                                  • Arthroplasty in patients with rare conditions
                                                    Open Access

                                                    Total knee arthroplasty in a patient with hypofibrinogenemia

                                                    Arthroplasty Today
                                                    Vol. 2Issue 4p177–182Published in issue: December, 2016
                                                    • Christopher R. Nacca
                                                    • Kalpit N. Shah
                                                    • Jeremy N. Truntzer
                                                    • Lee E. Rubin
                                                    Cited in Scopus: 2
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                                                      Patients with afibrinogenemia or hypofibrinogenemia present a unique challenge to the arthroplasty surgeon as fibrinogen is a key contributor to hemostasis. Patients with these disorders are known to have a higher risk for postsurgical bleeding complications. We present the case of a patient with hypofibrinogenemia who underwent an elective total knee arthroplasty. Our colleagues in hematology-oncology guided us initially to achieve and maintain appropriate fibrinogen levels in the early perioperative period.
                                                      Total knee arthroplasty in a patient with hypofibrinogenemia
                                                    • Arthroplasty in patients with rare conditions
                                                      Open Access

                                                      Total joint arthroplasty in patients with chronic infectious liver disease

                                                      Arthroplasty Today
                                                      Vol. 2Issue 2p69–76Published in issue: June, 2016
                                                      • Jeremy N. Truntzer
                                                      • Kalpit N. Shah
                                                      • Derek R. Jenkins
                                                      • Lee E. Rubin
                                                      Cited in Scopus: 6
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                                                        The opportunity for total joint arthroplasty (TJA) in patients with chronic infectious liver disease is rapidly expanding. This is the product of both superior survival of chronic hepatitis patients, evolving implant technologies, and improvement of techniques in TJA. Unfortunately, treating this group of patients is not without significant challenges that can stem from both intrahepatic and extrahepatic clinical manifestations. Moreover, many subclinical changes occur in this cohort that can alter hemostasis, wound healing, and infection risk even in the asymptomatic patient.
                                                        Total joint arthroplasty in patients with chronic infectious liver disease
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